George Square and the surrounding buildings have a strong historical link with the development of science and technology in Glasgow. Statues in the Square itself pay homage to great scientists of the past, standards of measurement on the Square and at the City Chambers provide evidence of the Merchant City area's central role in Glasgow's trade, while the buildings about the Square were some of the first to benefit from the new developments in lighting and electricity.

The nearby Ramshorn Theatre (St David's Church) holds in its burial ground the remains of many successful merchants who made their fortunes in Glasgow at a time when the city embraced all the benefits that advances in science, technology and engineering could bring. The Science On The Streets tour highlights the fact that many of the men who made those advances were actually based in this city, that and their presence can still be felt every day when we walk Glasgow's streets.